The “ENDING AIDS, ENDING INEQUALITIES FAST-TRACK CITIES” report presents recent good practices from the 15 cities included in the joint UNAIDS-IAPAC Fast-Track Cities project supported by PEFPAR/USAID. It shows how cities are responding to HIV and other global health threats, building municipal capacity and strengthening partnerships, using data and spearheading innovation to protect and support their citizens. It further shows that, despite varying contexts and challenges, addressing inequalities and reaching those most vulnerable is central to advancing the HIV response towards ending AIDS by 2030.