The UNAIDS Secretariat, as co-convener of the Global Partnership for Action to Eliminate all Forms of HIV-related Stigma and Discrimination (Global Partnership), was tasked to develop this brief, based on consultations with its Technical Working Group (TWG), to provide evidence-informed guidance to countries on the intersection of stigma related to HIV and COVID-19 in national responses. UNAIDS thanks co-conveners and TWG members for participating in consultations, contributing their time and providing expert recommendations. This document is also available in Portuguese