This document offers guidance on why and how efforts to Fast-Track HIV prevention, testing and treatment services can and should be grounded in human rights. Beyond being an imperative in themselves, human rights principles and approaches are critical to addressing barriers to HIV services and to achieving HIV targets. Human rights principles and approaches will help maximize the reach and impact of HIV prevention, testing and treatment programmes. They also will help address potential human rights challenges and prevent abuses that may occur in the context of urgent efforts to Fast- Track the achievement of HIV prevention, testing and treatment targets.