There are still considerable inequities among the regions in terms of progress and challenges. The Special Envoys have concluded that everything they do must be sustainable and focused on closing the remaining gaps while also addressing the social and structural determinants of health. This is why it is essential to integrate efforts to end the AIDS epidemic throughout the sustainable development goals. The lessons learned and resources marshalled through more than three decades of the AIDS response can inform and empower the post-2015 development agenda to measurably improve the lives and health of people for generations to come.