We are encouraged by the progress made by countries in reducing the number of children newly infected with HIV. Two years have passed since the launch of the Global Plan, when countries embraced the goal of moving towards eliminating new HIV infections among children and keeping their mothers alive. Since then, there has been momentum in scaling up access to HIV prevention and treatment services for women and children – especially in the 21 Global Plan priority countries in sub-Saharan Africa. Ghana and South Africa have led the way, with the largest decreases in the numbers of new HIV infections among children from 2009 to 2012.