In the Middle East and North Africa (MENA) region, the HIV epidemic has been on the rise since 2001. Although the overall HIV prevalence in the region is still low, the rise in new infections has put MENA among the top two regions in the world with the fastest growing HIV epidemic. The rise in the estimated number of people living with HIV in the region presumably is the result of an increased HIV prevalence among key populations at higher risk and a forward transmission of the virus to a larger number of individuals who are generally at lower risk of infection.