UNAIDS and other partners, including the Global Coalition on Women and AIDS, the International Center for Research on Women and Tibotec Inc., have come together to create a movement to ‘Make HIV Trials Work for Women and Adolescent Girls’. The movement has been established to review past participation of women and adolescent girls in clinical trials; to assess how well HIV trials are collecting, measuring, analysing and presenting data related to health determinants and health outcomes in women or adolescent girls; and to identify barriers to including women and adolescents in trials. An action plan, developed to address these concerns, is being implemented.