This Best Practice report shows how the power of working people can be harnessed in the response to AIDS. Eleven case studies from different settings show how trade unions are mounting bold, imaginative responses to HIV in the workplace: challenging stigma and discrimination, addressing the factors that increase vulnerability and risk, educating their members on HIV transmission prevention, providing care and treatment, and building worldwide coalitions that campaign for more to be done to tackle the disease. The report contains a wealth of practical experience that trade unions, employers, governments and nongovernmental organizations can draw on when developing workplace responses to AIDS.