Discrimination, stigmatization and denial have been recognized as important issues to be addressed in the context of HIV/AIDS. Discrimination against those living with HIV/AIDS, or presumed to be infected, is a violation of human rights. All individuals deserve equal respect and dignity, whatever their situation and whatever their health status. This Key Material succinctly describes and compares findings from studies, conducted in India and Uganda, of the nature, determinants and effects of HIV/AIDS-related discrimination, stigmatization and denial. The comparative analysis demonstrates the profound consequences of these negative processes for the individuals, families and communities involved. Policy, programmatic and research issues are also highlighted.